• In the USAID Maternal Child Health

  2018-10-24

  

  In 2012, the USAID Maternal Child Health Integrated Program commissioned a comprehensive report on the state of “respectful maternity care” (RMC) across low and high resource countries (Reis et al., 2012). The authors concluded “safe motherhood must be expanded beyond the prevention of morbidity or

• br Introduction In order to obtain

  2018-10-24

  

  Introduction In order to obtain easy access to accurate material and Sulfo-NHS-LC-Biotin inventory data for the modelling of industrial bioprocesses at the early stages of process design, a Microsoft® Excel model has been developed, termed the CeBER Bioprocess Modeller (Centre for Bioprocess Eng

• The DHCR gene has been mapped

  2018-10-23

  

  The DHCR24 gene has been mapped to chromosome 1p32.3, a region commonly amplified in HCC and which may contribute to carcinogenesis (Yuan et al., 2003; Endo et al., 2009). Recently, two experienced mutations, Q88L and R311H, were identified in the DHCR24 gene in Korean HCC patients (Ahn et al., 201

• Interrogating the underlying pathophysiology prior to the fu

  2018-10-23

  

  Interrogating the underlying pathophysiology prior to the full-blown manifestations can help clarify some confounding effects. For example, extant neuroimaging research on established BP has suggested that the volume of gray matter (GM) decreases in the regions underpinning emotion processing and re

• br Author contributions br Acknowledgements br Introduction

  2018-10-23

  

  Author contributions Acknowledgements Introduction Diabetes type 2 is an epidemic public health problem. Poorly controlled diabetes results in accelerated microvascular disease and chronic debilitating morbidities and mortality (Beckman et al., 2002). Diabetic microvascular angiopathy is th

• Dengue is a climate sensitive mosquito borne viral disease

  2018-10-23

  

  Dengue is a climate sensitive mosquito-borne viral disease that is generally found in the tropics and subtropics (Murray et al., 2013). According to the World Health Organization (World Health Organization (WHO), 2012) and recent assessment on global burden of diseases (GBD2013) (Murray et al., 2015

• The cAMP pathway has been

  2018-10-23

  

  The cAMP pathway has been implicated in physiological and pathological learning, but cognitive enhancement in healthy individuals has not been previously observed. In Drosophila, cAMP signaling during development is required for fine-tuning mushroom-body output neurons, a key component of learning a

• Most of our DSAs were de novo and their development

  2018-10-23

  

  Most of our DSAs were “de-novo”, and their development was predicted by donor and recipient ages. Other studies reported younger age at LT and medication non-compliance to be predisposing factors, which was not confirmed in our cohort (Del et al., 2014). Only three children developed both Class II D

• nitric oxide inhibitor In light of the preceding findings th

  2018-10-23

  

  In light of the preceding findings, the study by Darville and colleagues () is timely. They explored the therapeutic potential of more than 200 pharmacological agents, using neurons differentiated from iPS cells derived from ASD individuals heterozygous for null mutations. Darville et al. applied a

• The detection of ODC derived DeMeth MOG DNA in

  2018-10-23

  

  The detection of ODC-derived DeMeth MOG-DNA in the cuprizone mouse model lead us to examine the methylation state of the MOG gene in human DNA. Analysis of an evolutionarily conserved region of MOG-DNA in human brains and liver showed an identical demethylation pattern in CpG dinucleotides also pres

• We profiled AR and MYC binding to

  2018-10-23

  

  We profiled AR and MYC binding to chromatin and found that they co-occupy circa one third of the binding sites. We performed RIME and immunoprecipitation experiments in order to comment on how MYC antagonises AR activity but we did not find evidences of direct interaction between the two transcripti

• Future considerations must be given to host pathogen

  2018-10-23

  

  Future considerations must be given to host-pathogen interactions that can also influence drug susceptibility. (1) Animals, including primates, often tolerate drugs differently than humans (pharmacokinetic parameters such as drug clearance, volume of distribution, and half-life can result in unantic

• mth1 inhibitor Our systematic review demonstrated that the m

  2018-10-23

  

  Our systematic review demonstrated that the majority of NOD2-smoking studies were underpowered to detect an interaction; for example, 10 identified studies included fewer than 300 participants (de Diego et al., 2006; Giachino et al., 2004; Laghi et al., 2005; Mardini et al., 2005; Mendoza et al., 20

• A successful vaccine should lead to the generation

  2018-10-23

  

  A successful vaccine should lead to the generation of long-lived plasma cells and memory B cells that are thought to be essential for sustained humoral immunity. However, during chronic infection, the persistence of viral diindolylmethane alters B cell differentiation into memory cells (Colineau et

• Even if the DP of

  2018-10-23

  

  Even if the DP of the method calculated from this study is >0.99 (DP=0.995, as compared to 0.992 in our previous study (Gits-Muselli et al., 2015)), the distance between P. jirovecii genotypes remains low using our MLP typing method, resulting in a limited number of genetic groups. This low genetic

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