• These agents can be divided

  2021-12-01

  

  These agents can be divided into three categories based upon the therapeutic agent conjugated to the antibody; the most frequently explored are ADCs using a cytotoxic agent to be delivered directly to the tumor site. The second class has not been broadly used and consists of radionucleotides (Wong e

• SP600125 Carbon monoxide another key product from the breakd

  2021-12-01

  

  Carbon monoxide, another key product from the breakdown of heme by HO-1, also plays an important role in the vasculature. Like NO, CO is endogenously derived from the endothelium [68] and can weakly activate sGC by binding to its heme moiety [69]. CO was found to have vasodepressor activity in rats

• We have shown previously that activation of the TGF

  2021-12-01

  

  We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates dihydrofolate reductase inhibitor cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-g

• ML-291 br Introduction The Ras superfamily of small GTPases

  2021-12-01

  

  Introduction The Ras superfamily of small GTPases is composed of more than 150 protein members involved in a wide variety of biological processes, such as proliferation, differentiation, cytoskeletal organization, and protein trafficking [1]. The Ras superfamily proteins act as molecular switches

• One of the most common dietary approaches against

  2021-12-01

  

  One of the most common dietary approaches against obesity-associated diseases is the increase in the consumption of ω3 polyunsaturated fatty acids [18], [19]. Since seminal paper by Bang and Dyeberg in which the low prevalence of coronary heart disease among the Inuit was associated with the high ma

• We suggest that the FRET enhancement observed when

  2021-12-01

  

  We suggest that the FRET enhancement observed when the modified mD1 protein containing Acd at position 28 was excited at 260nm (), may differ from the diminution in fluorescence observed following excitation at 280nm due to the excitation of different transitions in Trp (i.e., the L and L transition

• br Materials and methods br

  2021-11-30

  

  Materials and methods Results Discussion Although large-scale purification of homogeneous and functional membrane proteins is challenging, it is essential for biochemical, biophysical and structural characterization. This is particularly true for human P-gp, as its atomic structure has only

• Though regulation of ghrelin interaction with GHSR has not b

  2021-11-30

  

  Though regulation of ghrelin interaction with GHSR has not been described previously, a precedent for a similar regulatory mechanism exists in the form of the interaction between Agouti-Related Protein (AgRP) and melanocortin receptor subtypes MC3R and MC4R (Ollmann, 1997). AgRP is produced by hypot

• br Conclusion and future directions GS is an

  2021-11-30

  

  Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS

• In order to ensure that the decrease in

  2021-11-30

  

  In order to ensure that the decrease in ethanol and morphine intake was not due to a sedative effect of SNAP 37889, locomotor activity and motor learning were assessed through behavioural paradigms. Using the locomotor test, SNAP 37889 did not alter any parameters of locomotion; this lack of sedatio

• In stark contrast to this study Zhang and colleagues

  2021-11-30

  

  In stark contrast to this study, Zhang and colleagues demonstrated that FFA4, along with FFA1, play roles in suppressing cell proliferation and promoting apoptosis in CRC sh4 treated with omega-3 PUFA [53]. In this study design, in vivo CRC was induced in mice upon treatment with the genotoxic colon

• So what makes a FFAR agonist different and interesting

  2021-11-30

  

  So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept

• Mitochondria are also involved in other

  2021-11-30

  

  Mitochondria are also involved in other modalities of programmed cell death, particularly apoptosis. Intriguingly, the roles of mitochondria in apoptosis and ferroptosis are fundamentally different. In mitochondria-mediated apoptosis, the mitochondrion serves as a reservoir, storing apoptosis-regula

• Through experimental models and clinical experiments those f

  2021-11-30

  

  Through experimental models and clinical experiments, those four drugs above can shown efficacy-enhancing and toxicity-reducing effects after compatibility. Our preclinical studies showed that XFC has a definite effect on relieving joint symptoms in RA patients. XFC can improve joint pain, swelling,

• We conclude that a combination of GD specific

  2021-11-30

  

  We conclude that a combination of GD2-specific CAR T cell therapy with pharmacological EZH2 inhibition deserves investigation as a new therapeutic strategy in EwS and potentially other cancers with heterogeneous GD2 expression, including osteosarcoma, various soft tissue sarcomas, melanoma, lung can

15697 records 519/1047 page Previous Next First page 上5页 516517518519520 下5页 Last page