• Itch also known as astrophin interacting protein AIP

  2020-11-30

  

  Itch, also known as astrophin-1 interacting protein-4 (AIP4), is a HECT domain-E3 ligase. It was discovered in 1998 in mouse coat color genetic studies which displayed the disruption caused by the Itch gene inducing a lethal autoimmune inflammatory condition. The substrates of Itch are transmembrane

• br Effect of DPP Inhibitors on the Clinical Course of

  2020-11-28

  

  Effect of DPP-4 Inhibitors on the Clinical Course of Heart Failure Four large-scale cardiovascular outcomes trials with DPP-4 inhibitors have been completed, and their findings have been published (Table 1) 31, 32, 33, 34. In 2 studies (with saxagliptin and alogliptin), DPP-4 inhibition was accom

• More recently Boskovic et al have

  2020-11-28

  

  More recently, Boskovic et al. (2003) have visually corroborated that purified DNA-PKcs can bind short DNA fragments by using single particle EM. DNA biotinylated at the 5′ end was labelled by coupling to commercial streptavidin–gold particles (Fig. 4D). When analysed in the microscope, DNA-PKcs mol

• Previous studies have indicated that hSSB may be phosphoryla

  2020-11-28

  

  Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho

• LX7101 HCL To date many studies have reported significant ab

  2020-11-28

  

  To date, many studies have reported significant aberrant methylation patterns in TIMPs in various types of cancer LX7101 HCL [[16], [17], [18]]. However, little has been reported on the events that lead to the methylation of TIMPs in the UV-irradiated human skin. Therefore, the objective of this st

• br Experimental Procedures br Acknowledgments br Introductio

  2020-11-28

  

  Experimental Procedures Acknowledgments Introduction Incessant consumption of fossil fuels brings on global energy crisis and serious environmental concerns. Hence, the researchers have paid considerable attention to alternative renewable bioenergy. Microalgae has been considered as potenti

• Dehydrogenation by a KSTD is also a crucial

  2020-11-28

  

  — 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during carboxypeptidase degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic steroi

• We had earlier reported that

  2020-11-28

  

  We had earlier reported that collagen fibers with intact native banded structure were occasionally observed in the kinase-deficient, membrane-anchored DDR2 ECD (DDR2/-KD) samples; however, in our DDR1/ECD and DDR2/ECD samples, observation of native banded structure of collagen was far more infrequen

• br Conclusion Our objective is to promote cell activity on

  2020-11-28

  

  Conclusion Our objective is to promote cell activity on biomaterials, especially for use in regenerative medicine, by grafting THPs containing collagen-binding sites onto inert substrates. We have previously reported a methodology to derivatize EDC/NHS crosslinked films with photoreactive THPs. T

• As a basis for the DDR substrate

  2020-11-28

  

  As a basis for the DDR1 substrate identification approach detailed below, we first set out to perform 2D-gel electrophoresis with lysates isolated from collagen-stimulated human breast cancer MDA-MB-231 nf-κb pathway overexpressing DDR1 (b-isoform). This allowed us to determine whether DDR1 is not

• br Hypothesis on DDR protective mode

  2020-11-28

  

  Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci

• br Funding This work was supported

  2020-11-28

  

  Funding This work was supported by a research grant of the Deutsche Forschungsgemeinschaft (SCHN477-9-2 to R.S.S), the Manfred-Stolte-Stiftung (to R.S.S.) and by a research grant from the German Cancer Aid (Deutsche Krebshilfe, No. 106696/TP 5 to T.F.). Introduction Death-associated protein k

• br CDK Regulators as Coactivators of NF B and

  2020-11-28

  

  CDK Regulators as Coactivators of NF-κB and STAT CDK regulating proteins also have the ability to control the inflammatory response. The p21CIP1 protein binds to and inhibits the activity of cyclin–CDK4/6 and cyclin–CDK1/2 complexes. Consistent with its ability to inhibit CDK activity, deletion o

• Within the Class II receptors the Type

  2020-11-28

  

  Within the Class II receptors, the Type I IFN receptor subunit, IFNAR-1, is exceptional in having four tandem FNIII domains, denoted here D1–D4. This structure appears to have arisen as a tandem R406 of the basic D1/D2 structure; thus, D1 and D3 of IFNAR-1 are more closely related, as are D2 and D4

• DNA methylation is a relatively stable but reversible

  2020-11-28

  

  DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla

15697 records 726/1047 page Previous Next First page 上5页 726727728729730 下5页 Last page