• Nowadays colorimetric assay has been applied

  2020-01-02

  

  Nowadays, colorimetric assay has been applied in detecting DNA MTase activity. Li et al. used DNA modified gold nanoparticles (AuNPs) coupled with enzyme-linkage reactions to detect the activity of methylases [20]. In a previous study, our group presented a label-free colorimetric method, using unmo

• In the present study we

  2020-01-02

  

  In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis 360A mg and leaves, we demonstrate that this sub-class of plant proteases is activated in resp

• In the present study Asian swamp

  2020-01-02

  

  In the present study, Asian swamp eel CXCR1a (MaCXCR1a), MaCXCR1b, MaCXCR2, MaCXCR3a, MaCXCR3b, and MaCXCR4 were identified from the Asian swamp eel genome. To explore the features and functions of these CXCRs, we focused on the identification and molecular characterization of MaCXCRs, and Bedaquili

• Interestingly all three lesions that significantly inhibited

  2019-12-31

  

  Interestingly, all three lesions that significantly inhibited transcription – CPD, εA and the AP site, – promoted insertion of Flubendazole residues opposite the damaged nucleotide. Thus, bacterial RNAP seems to follow the so-called ‘A-rule’ for incorporation of nucleotides opposite AP-sites and bu

• Besides chemopreventive effects against oxidative

  2019-12-31

  

  Besides chemopreventive effects against oxidative DNA damage we evaluated the protective effects of the three Hypericum sp. and isolated compounds against alkylating DNA damage induced by MMS in HT29 cells. Human exposure to alkylating agents, from different sources, occurs in a continuous way and i

• During the past three decades platinum based DNA alkylating

  2019-12-31

  

  During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot

• Members of the Nudix family

  2019-12-31

  

  Members of the Nudix family typically contain a 23-amino-acid sequence (Nudix box) of GxExREUxEExGU, where U is usually Ile, Leu, or Val and x represents any amino acid. The EUxEE core residues serve as anchors for an Mg ligand that associates with a characteristic pyrophosphate linkage that is comm

• br Experimental section br Results br

  2019-12-31

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised Imatinib sale did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient

• In this study new and more extended tables of

  2019-12-31

  

  In this study, new and more extended tables of parameters were estimated for pure fluids and binary mixtures that are relevant to biodiesel systems. Also, calculations for glyceride systems will be shown, which is a topic not investigated before with the CPA model. As before [21], [22], [23], [24],

• Park et al expanded their own model

  2019-12-31

  

  Park et al. [34] expanded their own model as hydrogen- bonding lattice fluid EOS (NLF-HB) [35] for calculating the activity coefficients of aqueous amino prostaglandin receptor solution. Further, Pazuki et al. [36] extended the perturbed hard chain theory which has been proposed by Beret and Prausn

• Errors are detected by comparing the output data against an

  2019-12-31

  

  Errors are detected by comparing the output data against an error free reference. After error detection, the process is restarted so that only one error is accounted. The susceptibility is inferred by the ratio between injected events and detected errors: = 100×errors÷events%. Error rates are obtai

• It is well known that Doxorubicin

  2019-12-31

  

  It is well known that Doxorubicin-induced cardiotoxicity occurs via p53-mediated apoptosis (Lorusso et al., 2007). However, there are few studies elucidating the mechanism of HFS induced by PLD. We found that PLD induces keratinocyte apoptosis in a very low dose, and the damage induced by PLD cannot

• The use of the periplasmic fraction as starting material

  2019-12-31

  

  The use of the periplasmic fraction as starting material and the presence of a unique purification step concurred in improving the purification yield to 25.3%, which is significantly higher than what obtained with the previous purification protocol (6.7%). In addition, the analysis of the kinetic co

• Cantharidin is a natural element extracted

  2019-12-31

  

  Cantharidin is a natural element extracted from blister beetles, and has been proven to be effective in cancer [16]. NCTD, the demethylated analog of cantharidin, has been synthesized and been shown to have an equal anti-cancer effect with fewer side effects than cantharidin [39]. It was confirmed t

• The work described by Dong

  2019-12-31

  

  The work described by Dong, Groves, and co-workers (11) tested the hypothesis that neural stem cell development is sensitive to the clustering and mechanical state of the EphB4:ephrin-B2 receptor-ligand complex. They show that the quality of ephrin-B2-ligand signaling depends on its biophysical stat

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